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Company Name:                       LanzaTech,Inc.

Position Title:                           Senior Computational Biology Scientist

Location:                                  8045 Lamon Ave, Suite 400, Skokie, IL 60077

Days/Hours:                             Mon – Fri / 9 a.m. to 5 p.m.

Job Summary:   

Apply computational techniques to design and implement software and information management tools to solve complex computational and mathematical problems in biology.  Provide feedback to experimentalist on experimental design so as to downstream analysis and work collaboratively with other computer scientists on computational research in a fast-paced environment. Scope scientific problems and translate into actionable software solutions using the agile design principles of incremental and iterative design. Collaborate and liaise across teams and departments to integrate data analysis and software development into larger context. Discuss genomics, metabolomics, transcriptomic and mutational data sets, including complex statistical summaries; communicate results to synthetic biology scientists, fermentation scientists, and engineers. Stay abreast of developments in the field by attending conferences such as Generic Model Organism Database and working through online course to gain new data analysis skills and attending formal workshop. Prepare and update protocols and SOPs for bioinformatics, statistics and next generation sequencing. Liaise with collaborators, service providers and vendors. Collaborate with National Laboratories and other universities on Bioinformatics and data analysis projects. Liaise with service providers such as Illumina, MacroGen to procure products and services within timeframes. Source service providers and equipment purchases. Present findings and data in verbal presentation, through written summaries and PowerPoint presentations, at weekly group meetings, periodic company-wide “wall-talks”, and externally at conferences and symposiums.

Required Minimum Position Qualifications:          

Master’s degree in Bioinformatics, Computer or Information Science or a closely related field and two (2) years of experience in the job offered or closely related occupation with the following: Gene calling with at least two of the following software tools: Glimmer, Prodigal, GeneMark; Genome sequence analysis with at least eight (8) of the following software tools: BLAST, HMMR, RNAmer, Aragorn, Ant–SMASH, tRNA-scan, Infernal, Blast2GO, Velvet, PSORT or RAST; RNAseq analysis with at least five (5) of the following software tools: Cufflinks, DESuq, edgeR, BAM and SAM tools, Rock-hopper; Variant calling using SAM tools, Bowtie, and GATK; Public genome database resources (HEGG, PFAM, NCBI, MetaCyc, BRENDA, or GOLD/IMG); Programming in R environment; Data mining in the Weka environment; Either Perl/BioPerl programming or Python/BioPython programming; Configuring JBrowse genome browser; Configuring Geneious shared database; Configuring both Tripal and ChadoDB; HTML programming; JavaScript programming with at least two (2) of the following: jQuery, Node.js or D3.js; CSS programming; PHP programming with Symphony 2.0; Dynamic website design and implementation of Ajax paradigm; data modeling; database design; database administration with both MySQL and Postgre SQL; Bash Shell programming; Linux Network and Systems programming; implementation of active directory authentication; and firewall set-up and administration. 

To apply, mail resume to LanzaTech, Inc. HR, 8045 Lamon Ave., Suite 400, Skokie, IL 60077. Please reference job code  #LZTUS003

 

 

 

 

Company Name:                       LanzaTech,Inc.

Position Title:                           Research Scientist

Location:                                  8045 Lamon Ave, Suite 400, Skokie, IL 60077

Days/Hours:                             Mon – Fri / 9 a.m. to 5 p.m.

Job Summary

Identify and design new pathways and constructs for metabolic engineering of LanzaTech bacteria including combinatorial assembly of biochemical reaction genes. Conduct genetic modification of LanzaTech bacteria, including expression of pathways on plasmids and generation of gene knockouts in Clostridia. Conduct DNA assembly, including extraction of DNA fragments, plasmids and scarless cloning. Conduct growth experiments to assess productivity of LanzaTech bacteria for new products including development of high-output gas fermenting platform. Perform Genome Scale Model (GSM) simulations to evaluate novel strains and curate LanzaTech’s model, including in silico simulation of gene knockout/knock in, expression of heterologous pathways, and evolutionary strain optimization for enhanced product formation. Analyze modeling results, and upload modeling results to maintain electronic archives while suggesting enhancements and additions to modelling platform. Work in cross-functional project teams. Prepare documentation as presentations or text for team meetings, patents, grant proposals, and publications. Participate in preparation of grant applications. Analyze and discuss relevant literature, patents, and development of new concepts, as well as literature research, to identify new tools and pathways to troubleshoot problems. Communicate results and development of standard methods and operating procedures. Maintain laboratory books and records and report inventions to patent attorney. Contribute to and adhere to all safety standards and practices. Conduct regular conference calls to discuss updates.

Required Minimum Position Qualifications:          

PhD in Biology or a closely related field of study and one (1) year of experience in the job offered or closely related occupation. In lieu of a PhD in Biology or a closely related field of study and one (1) year of experience in the job offered or closely related occupation , employer will accept a Master’s Degree in Biology or a closely related field of study and 3 years of experience in the job offered or a closely related occupation. Applicants must have demonstrated experience with the following: Metabolic engineering; Genome scale modelling; Fermentation; Design of metabolic pathways; Design of combinatorial libraries; Assembly of DNA (conventional and ligation independent cloning); DNA design software (Geneious or Vector NTI); Genome modification techniques; CRISPR; Allele-coupled exchange (ACE); Curation of genome scale models; Running genome scale model simulations including Minimization of Metabolic Adjustment (MOMA) and Parsimoneous Flux Balance Analysis (pFBA); Bench-scale fermentation; Cultivation, transformation, screening and growth/production studies of bacteria in laboratory setting; Gene overexpression; Protein purification; HPLC; GC; Microbial metabolism; Enzyme kinetics; Fermentation processes; Design of Experiment; Statistical analysis; Work published in high impact journals; Patent applications; and Preparation of grant proposals.

To apply, mail resume to LanzaTech, Inc. HR, 8045 Lamon Ave., Suite 400, Skokie, IL 60077. Please reference job code  # LZTUS004

 

 

 

 

 

 

 

 

 

Company Name:                    LanzaTech Freedom Pines Biorefinery LLC.

Position Title:                         Instrument and Software Engineer

Location:                                 535 Commerce Drive, Soperton, GA 30457

Days/Hours:                           Mon – Fri / 9 a.m. to 5 p.m.

 

Job Summary:

Develop implementing process control strategies in R&D and production facilities globally. Work with Plant Engineers, Engineering Design Team and Operators to review programming requirements and implement code for various projects in a safe, communicative manner. Work with departments and other engineers to develop alternatives and estimates for proposed capital and major maintenance projects. Support the maintenance team responsible for ensuring the continuous operation, proactive maintenance, monitoring and enhancement of the mission critical process control systems and data acquisition. This also includes proper analysis of risks vs. needs regarding software updates. Assist in training and knowledge sharing with operators and instrumentation technicians on process control systems to help improve their operating and troubleshooting effectiveness. Provide input in design and development of LanzaTech internal Lab information management system. Provide input in machine learning and automation of LanzaTech prosperity gas fermentation process. Direct plant software and hardware life-cycle management to minimize business risk in line with investment and acceptable risk tolerance. Serve as primary contact for external vendor interactions.

Required Minimum Position Qualifications:

Bachelor’s in Engineering or a closely related field of study and five (5) years of experience in the job offered or closely related occupation  with working in a lab environment; National Instruments LabVIEW and SQL database programming; working with process control systems Emerson Delta-V and Allen Bradly; working with instrumentation and data acquisition; acquiring, translating, documenting requirements and developing experimental workflows in a scientific organization; Understanding of agile software development and technologies such as .NET, C#, HTML, CSS; computer networking and Window operating system environment; assisting with capital projects from concept to installation, start-up and commissioning support.

To apply, mail resume to LanzaTech HR, 8045 Lamon Ave., Suite 400, Skokie, IL 60077. Please reference job code #LZTUS005